基于机器学习的初级膜性病患者静脉血栓塞栓风险预测模型的开发
Lian Li1,2, Liuyun Wu1, Yin Wang1
1Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Frontiers in pharmacology
|November 24, 2025
概括
这项研究开发了一种机器学习模型,用于预测一次性膜性病 (PMN) 患者的静脉血栓栓塞 (VTE) 风险. 该模型有助于个性化抗凝剂治疗决策,以改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 数据科学数据科学数据科学
- 医疗信息学 医疗信息学
背景情况:
- 初级膜性病 (PMN) 患者面临着静脉血栓塞栓症 (VTE) 的显著风险.
- 目前的预防性抗凝剂治疗缺乏针对PMN患者的个性化风险评估.
研究的目的:
- 开发和验证基于机器学习的PMN患者VTE风险预测模型.
- 在临床实践中创建一个用户友好的实时VTE风险评估工具.
主要方法:
- 利用了来自643名PMN患者的现实数据,分为训练和测试集.
- 采用数据预处理技术,包括归算,采样和特征选择.
- 开发并比较了14个机器学习算法,选择了最佳的NGBoost模型,使用SHAP进行解释.
主要成果:
- 最优的NGBoost模型实现了0.911.1的AUC.
- 发现的关键预测因子包括D-二聚体,纤维素降解产物,INR,复发性性综合征,胆酶,尿中微专蛋白/肌素比率,他类药物,抗血素III活性,专蛋白和抗PLA2R抗体.
- 成功构建了一个基于网络的VTE风险预测工具.
结论:
- 使用机器学习开发了一个强大的,个性化的PMN患者静脉瘤风险预测模型.
- 开发的工具可以显著帮助临床医生做出关于在PMN患者中预防VTE的抗凝固药治疗的明智决策.
相关概念视频
Venous Thrombosis III: Interprofessional Care
268
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
268
Venous Thrombosis I: Introduction
321
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
321
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
277
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
277
Venous Thrombosis IV: Nursing Management
188
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
188


