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早期认知衰退的可扩展标记:血p-tau217,主观认知问题和数字测试:A4/LEARN研究的结果

Babak Khorsand¹, Devin Teichrow¹, Elham Ghanbarian¹

¹Department of Neurology, University of California, Irvine, CA, USA.

medRxiv : the preprint server for health sciences

|November 24, 2025

概括

血化tau 217 (p-tau217),主观认知问题和计算机认知测试可以预测老年人的认知衰退. 这些可扩展,非侵入性标记为早期风险分层和阿尔茨海默病预防试验提供了实用的工具.

科学领域:

神经科学是一个神经科学.
生物标志物生物标志物
老年学是指老年学的学科.

背景情况:

目前的阿尔茨海默氏病 (AD) 诊断 (粉样PET,脑脊液生物标志物) 对于广泛的查是不切实际的.
对于可扩展的人口评估,需要使用等离子体p-tau217,主观认知问题和计算机认知测试等非侵入性标志物.
早期识别面临认知障碍风险的个体对于及时干预和预防策略至关重要.

研究的目的:

评估血p-tau217的独立预测值,主观认知问题 (CFI) 和计算机认知测试 (CCB) 以确定发生的认知障碍.
确定这些非侵入性措施的结合是否会提高老年人认知能力下降的预后准确性.
评估这些标记物对无症状人群风险分层的有用性.

主要方法:

分析了来自A4试验和LEARN队列的65-85岁的1,071名认知正常成年人.
基线评估包括血p-tau217,认知功能指数 (CFI) 和Cogstate计算机化电池 (CCB).
事件认知障碍是由全球临床痴呆症评分得分 (CDR-GS) 在240周的进展中定义的.

主要成果:

34.1%的参与者在随访期间出现认知障碍.
较高的血p-tau217,较高的CFI和较低的CCB分数独立预测了认知障碍的可能性增加.
每个标记在一起分析时仍然具有统计学意义,表明独立的预测能力.

结论:

血p-tau217,主观认知问题和计算机认知测试是未受损的老年人认知衰退的独立预测因素.
这些可扩展的非侵入性措施为临床诊断前几年早期风险分层提供了实际工具.
结合这些标记物可以提高临床环境中的早期检测,并提高阿尔茨海默氏症预防试验入学效率.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的疾病.认知能力下降认知能力下降数字生物标志物数字生物标志物血生物标志物血生物标志物主观认知问题主观认知问题

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