在纵向研究中量化疼痛的解剖部位的个体内变异性
Victoria J Madden1,2, Gwen Arendse1, Peter Kamerman3
1African Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
medRxiv : the preprint server for health sciences
|November 24, 2025
概括
研究人员开发了一种新指标来跟踪艾滋病毒感染者的个人疼痛位置随时间变化. 这一指标有助于理解疼痛的变化及其与疼痛严重程度和痛苦的联系.
科学领域:
- 疼痛研究 疼痛研究
- 慢性疼痛管理 慢性疼痛管理
- 艾滋病毒/艾滋病临床研究
背景情况:
- 纵向疼痛研究对于理解个体内疼痛变异至关重要.
- 现有的量化疼痛程度的方法缺乏捕捉时间和多地点变化的能力.
- 需要衡量疼痛经历随时间推移的动态性质的指标.
研究的目的:
- 描述个人内疼痛部位随时间变化的模式.
- 开发一种新的指标来量化疼痛部位的时间变化.
- 评估这个指标与疼痛负担指标之间的关系,例如疼痛严重程度和情绪困扰.
主要方法:
- 利用了72名HIV病毒被抑制的参与者的纵向队列数据.
- 收集了49周的每周关于疼痛严重程度,疼痛部位和情绪困扰的自我报告.
- 使用参与者数据开发和验证了一种"疼痛部位变异指标".
主要成果:
- 参与者报告显示,随着时间的推移,疼痛部位发生了显著的个体内变化.
- 开发的指标成功量化了疼痛部位的时间变化,并根据变异性区分了个体.
- 该指标显示了与疼痛严重程度和情绪困扰 (未调整) 的积极关联.
结论:
- 一个新的指标有效量化了疼痛部位的个体时间变化.
- 这一指标显示了与疼痛负担的关键指标的关系.
- 该指标为调查疼痛部位变异性对整体疼痛负担和临床结果的贡献提供了有价值的工具.
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