Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

432
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
432
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

378
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
378
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

449
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
449
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

693
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
693
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

316
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
316

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Utilization and Outcomes of Permanent Pacemakers After Bicaval Heart Transplantation: A Large Institutional Experience.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Capturing Cardiomyocyte Cell-to-Cell Heterogeneity via Shotgun Single Cell Top-Down Proteomics.

bioRxiv : the preprint server for biology·2026
Same author

Evaluation of Women With Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study.

Circulation. Genomic and precision medicine·2026
Same author

Guiding Principles: Reporting Elements for Gastrointestinal Organoid Research.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Development and validation of a tumor-derived CXCL1 qPCR assay to support patient selection for anti-CXCL1 therapeutics in bladder cancer.

Experimental and molecular pathology·2026
Same journal

Predicting Chemotherapy Response from Staging Laparoscopy Images.

medRxiv : the preprint server for health sciences·2026
Same journal

Development and External Validation of a Machine Learning Model for 10-Year Ischemic Stroke Risk Prediction in Diverse Populations.

medRxiv : the preprint server for health sciences·2026
Same journal

MCH-Guard: Multimodal Machine Learning Framework for Risk Stratification of Cerebral Microhemorrhage Risk in the Alzheimer's Disease Neuroimaging Initiative.

medRxiv : the preprint server for health sciences·2026
Same journal

Genetic and maternal environmental contributions to estimated fetal weight at 20 weeks gestation compared with birthweight.

medRxiv : the preprint server for health sciences·2026
Same journal

Better immediate declarative memory is associated with forgetting during locomotor adaptation in chronic stroke and in older adults.

medRxiv : the preprint server for health sciences·2026
Same journal

An empirical Bayes framework for burden and dispersion association tests helps prioritize rare variants associated with Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
查看所有相关文章

相关实验视频

Updated: Jan 10, 2026

In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes
08:19

In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes

Published on: June 22, 2020

7.0K

埃克森利用改善了Titin心肌病中高级心力衰竭的风险分层.

Peter Deckerman, Jihyeon Lee, Aleksandra Binek

    medRxiv : the preprint server for health sciences
    |November 24, 2025
    PubMed
    概括
    此摘要是机器生成的。

    丁丁 (TTN) 基因的切断变异是扩张性心肌病的常见原因. 一种新的方法,PSI-LR,使用长时间读取的RNA测序,准确地预测TTN变异载体中进展到晚期心力衰竭的风险.

    更多相关视频

    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
    12:45

    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

    Published on: December 11, 2017

    10.9K
    Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
    10:39

    Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

    Published on: August 30, 2024

    1.3K

    相关实验视频

    Last Updated: Jan 10, 2026

    In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes
    08:19

    In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes

    Published on: June 22, 2020

    7.0K
    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
    12:45

    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

    Published on: December 11, 2017

    10.9K
    Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
    10:39

    Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

    Published on: August 30, 2024

    1.3K

    科学领域:

    • 心血管遗传学 心血管遗传学
    • 分子心脏病学分子心脏病学
    • 基因组医学是基因组医学.

    背景情况:

    • 蒂 (TTN) 基因中的切断变异是扩张性心肌病 (DCM) 最常见的遗传原因.
    • 与TTN变异相关的DCM的临床严重程度和进展受到基因表达水平的影响,特别是受影响外型的百分比拼接 (PSI) 的百分比.
    • 使用短读RNA测序 (PSI-SR) 的现有方法可能无法完全捕捉TTN异型表达的复杂性.

    研究的目的:

    • 开发和验证一种新型指标,PSI-LR,使用长读RNA测序来更准确地量化TTN外子表达.
    • 评估PSI-LR能够预测TTN变异患者中进展到晚期心力衰竭 (AHF) 的风险的能力.
    • 建立一个PSI-LR值,用于识别患有AHF进展风险较低的患者.

    主要方法:

    • 对来自器官捐献者和DCM患者的心脏组织进行长读RNA测序,以识别和量化TTN异型.
    • 基于长读数据计算了一个新的指标PSI-LR,并与从短读数据中获得的PSI-SR进行了比较.
    • 分析了98名患有TTN变异的DCM患者队列,以将PSI-LR和PSI-SR与AHF的发展相关联 (根据LVAD或移植的需要来定义).

    主要成果:

    • 长读RNA测序确定了16种TTN异型,并揭示了与PSI-SR.相比,PSI-LR在5%的病例中重新分类了外子表达.
    • PSI-LR,但不是PSI-SR,显著预测了TTN变异患者的AHF进展风险 (OR1.35每0.1增加,p=0.038).
    • 低于0.75的PSI-LR值有效识别了没有进展到AHF的患者.

    结论:

    • 从长时间读取的RNA测序中获得的PSI-LR指标,提供了对DCM相关的TTN异型表达的更准确的评估.
    • PSI-LR是一种有价值的预测生物标志物,用于评估患有TTN变异的个体中进展到晚期心力衰竭的风险.
    • 这种改进的预后工具对TTN相关心肌病患者的临床管理和监测有重大影响.