纵向的症状过渡预测了巴西被剥夺自由的人群发生结核病的风险
Esther Jung1, José Victor Bortolotto Bampi2, Alessandra Moura da Silva2
1Stanford University School of Medicine, Stanford, California.
medRxiv : the preprint server for health sciences
|November 24, 2025
概括
随着时间的推移,监测症状可能会改善结核病查. 在研究期间出现新的症状与较高的结核病 (TB) 风险有关,与持久症状不同.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 临床试验方法论 临床试验方法论
背景情况:
- 结核病 (TB) 查通常使用一次性时间点症状检查.
- 纵向追踪结核病症状以检测结核病的价值仍未得到充分探索,特别是在高风险人群中.
研究的目的:
- 评估与结核查的横截面评估相比,纵向症状监测的额外好处.
- 在一组被监禁男性中调查症状发展和发生结核病之间的关联.
主要方法:
- 一项前性队列研究涉及巴西2282名被监禁的男性,最初没有结核病.
- 每四个月定期评估症状和发生的结核病诊断 (Xpert或培养阳性).
- 基于症状状况随时间变化的统计分析来比较结核病风险.
主要成果:
- 在进入研究时,23%的参与者报告了症状.
- 在两年内,43%的最初无症状个体出现了症状.
- 新症状的出现与发生结核病的风险增加有显著的关联,而持续症状则没有.
结论:
- 纵向症状监测在结核病查中比单次时间点评估具有潜在的优势.
- 追踪症状的演变可以提高在惩戒机构对结核病风险较高的个体的识别.
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