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视觉图像和频谱症状 抑郁症和低迷症在情绪面部预测和编码过程中不同调节大脑反应
Anna Manelis1, Skye Satz1, Rachel Miceli1
1Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA.
medRxiv : the preprint server for health sciences
|November 24, 2025
概括
视觉图像的生动性影响大脑对情绪面孔的反应情绪障碍. 抑郁症状会影响前极-双极区域,而低躁的特征会影响后部区域,这表明影像作为治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 抑郁症和双相情感障碍涉及情感信息处理偏见.
- 抑郁症的特征与负面偏见相关,低躁症的特征与积极偏见相关.
- 视觉图像的生动性可能会调节这些情感偏见.
研究的目的:
- 为了研究终身抑郁症和催眠症症状如何与图像生动性相互作用.
- 检查预期和编码情感面孔时对大脑激活的影响.
主要方法:
- 155名参与者 (BD,DD,HC) 在情感面部任务期间接受了fMRI.
- 评估终身抑郁症/催眠症 (MOODS-SR) 和图像生动度 (VVIQ).
- 使用FSL的三明治估计器分析了相互作用效应.
主要成果:
- 低迷症得分与生动性相关,并增加了快乐与悲伤面部的尾部活化.
- 在期待快乐与悲伤的面孔时,前中心旋转部激活的减少.
- 抑郁症症状与默认模式网络中的生动性相互作用,影响了前极和角圆圈激活.
结论:
- 抑郁和躁狂症状与视觉图像相互作用,影响情绪面部处理.
- 在前极-双极区域观察到抑郁偏差;在脑后皮层观察到低狂偏差.
- 图像的生动性是情绪障碍的潜在跨诊断干预目标.
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