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Updated: Jun 15, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
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一个灵活和响应的远程研究设计,用于评估野火烟雾暴露期间的基因表达变化,使用homeRNA,一个家庭血液采样套件

A J Haack1,2, L G Brown1, Y Zeng1

  • 1Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.

medRxiv : the preprint server for health sciences
|November 24, 2025
PubMed
概括

这项研究引入了家庭RNA,一个在家收集血液的套件,以分析野火烟雾对基因表达的影响. 灵活的方法捕获了转录组变化,揭示了高暴露个体的炎症和免疫反应变化.

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...