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在一个大型社区的美国队列中,心脏代谢风险和结构性大脑发育
Dani Beck1, Lars T Westlye2,3,4, Christian K Tamnes1,5
1PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
medRxiv : the preprint server for health sciences
|November 24, 2025
概括
年轻人的心脏代谢健康状况较差对大脑发育的影响很小. 虽然较高的体重指数与较薄的皮质相关,但整体大脑结构在很大程度上不受心脏代谢风险因素的影响.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 心脏代谢风险因素在儿童和青少年中越来越普遍.
- 在这些关键年份,心脏代谢健康和大脑发育之间的关系尚不清楚.
研究的目的:
- 研究10-17岁青少年心脏代谢健康和大脑结构/微观结构发育之间的关联.
- 为了确定较差的心脏代谢健康是否影响大脑发育轨迹.
主要方法:
- 利用了来自青少年大脑认知发展研究的3个波的3,527名参与者 (4,433个观察) 的数据.
- 分析了人体,心血管和代谢指数与皮质厚度,表面积和白质完整性 (微分异型性,平均扩散性) 相比.
- 采用贝叶斯的多层次模型并进行敏感性分析,包括青春期状态作为共变量.
主要成果:
- 较高的体重指数与皮质厚度降低有关.
- 静止心率升高与白质平均扩散率的增加有关,随着时间的推移,这种效应会增强.
- 大多数其他心脏代谢指标与大脑结构没有显著的关联;心脏代谢健康的变化没有预测随后的大脑变化.
结论:
- 童年后期和青春期的大脑结构似乎在很大程度上适应心脏代谢风险因素的变化.
- 特定的心脏代谢指数可能会产生微妙的影响,但整体的大脑发育在青春期不会受到这些因素的强烈影响.
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