阳性Clostridioides difficile测试不会影响急性严重性结肠炎住院患者的结果
Geethanjali Rajagopal1, Raghavendra Paknikar2, Zifeng Deng2
1Department of Internal Medicine, University of Chicago Medicine, 5841 S. Maryland Avenue, Suite MC7082, Chicago, IL 60637, USA.
Therapeutic advances in gastroenterology
|November 24, 2025
概括
在急性严重性结肠炎 (ASUC) 患者中,性结肠炎 (CDI) 感染并没有使住院时间或切除术率恶化. 建议在不推迟ASUC管理的情况下进行早期CDI诊断和治疗.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 内部医学 内部医学
背景情况:
- 克洛斯特里迪奥伊德困难感染 (CDI) 是急性严重性结肠炎 (ASUC) 患者的已知并发症.
- CDI对住院ASUC患者临床结果的影响需要进一步调查.
研究的目的:
- 评估诊断为CDI的住院ASUC患者的临床结果.
- 为了比较CDI阳性和CDI阴性ASUC队列之间的结果.
主要方法:
- 这是一项回顾性,单一中心研究,审查了从2008年12月到2018年6月的医疗记录.
- 首要结局的分析:住院时间,大肠切除率,免疫抑制升级.
- 二次结果的评估:再接收率,救援疗法的使用.
主要成果:
- 在410名ASUC患者中,有67人检测出CDI阳性.
- 没有观察到CDI阳性和CDI阴性组之间的住院时间,胆管切除率或再入院率的显著差异.
- CDI阳性患者接受静脉内皮质类固醇的可能性较低.
结论:
- 在ASUC患者中,阳性CDI测试与不良临床结果无关.
- 在住院的严重性结肠炎患者中,应排除CDI并及时治疗.
- 由于CDI诊断,ASUC的管理不应该被推迟.
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