冠状动脉疾病风险与代谢健康的转变相关,临床队列69 272人
Megan M Shuey1, Rebecca T Levinson2, Megan E Vogel3
1Division of Genetic Medicine and Clinical Pharmacology Vanderbilt University Medical Center Nashville TN USA.
Journal of the American Heart Association
|November 24, 2025
概括
过渡到代谢功能障碍是常见的,并迅速增加冠状动脉疾病 (CAD) 的风险. 体重变化也非线性地影响了CAD风险,突显了预防代谢功能障碍的干预措施的必要性.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 最近代谢功能障碍对冠状动脉疾病 (CAD) 风险的影响尚不清楚.
- 创建了一个大型数据集,将代谢表型与临床结果联系起来,量化与不良代谢过渡相关的CAD风险.
研究的目的:
- 量化与代谢功能障碍相关的冠状动脉疾病 (CAD) 的风险.
- 调查关于CAD风险的体重,代谢异常和代谢健康状况的变化之间的关系.
主要方法:
- 分析了844,981名患者的临床队列,将临床参数和代谢功能障碍组件 (糖尿病,高血压,高甘油三,低高胆固醇) 与发生的CAD联系起来.
- 对69272名受试者进行了时间到事件分析,以评估10年来代谢异常的发展及其与CAD风险的关联.
主要成果:
- 增加的体重指数,代谢功能障碍 (>2组件) 的存在,以及代谢异常的数量与普遍的CAD有关.
- 在最初健康的受试者中,大约38%的受试者在3年内发展出至少一种代谢异常. 新发病的新陈代谢异常和先前存在的新陈代谢异常都显著增加了10年CAD风险,随着异常负担的逐渐增加而相关联.
- 体重指数>25公斤/平方米的个体,10年CAD风险增加3.8倍. 短期权重波动也非线性地影响了CAD风险.
结论:
- 代谢功能障碍是一种常见且快速发展的疾病,显著增加了发生的CAD风险.
- 体重变化和CAD风险之间的关系是非线性的.
- 旨在防止代谢功能障碍进展的干预措施对于减少CAD发生率至关重要.
更多相关视频
13:07Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
4.3K
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
12.2K
相关概念视频
01:30Coronary Artery Disease I: Introduction
857
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
857
01:30Coronary Artery Disease III: Clinical Manifestations
311
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
311
01:26Coronary Artery Disease II: Pathophysiology
348
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
348
01:26Coronary Artery Disease IV: Preventive Measures
577
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
577
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
329
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
329
01:30Acute Coronary Syndrome III: Diagnostic Studies
200
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
200