使用隐性类分析识别糖尿病前期的心脏代谢亚型
Gulnaz Nuskabayeva1, Yerbolat Saruarov1, Karlygash Sadykova1
1Department of Special Clinical Disciplines, Medical Faculty, Khoja Akhmet Yassawi International Kazakh-Turkish University, Bekzat Sattarkhanov Street No. 29, Turkistan 161200, Kazakhstan.
Medical sciences (Basel, Switzerland)
|November 24, 2025
概括
前糖尿病是常见的和多样化的. 这项研究根据风险因素确定了四个不同的子组,表明需要个性化预防策略,而不是一种适合所有人的方法来管理糖尿病前期.
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 糖尿病前期影响全球数百万人,对2型糖尿病和心血管疾病构成重大风险.
- 早期识别糖尿病前期子组对于制定有针对性的预防策略至关重要.
- 糖尿病前期的异质性需要超越一般化方法.
研究的目的:
- 通过使用心血管风险因素,在糖尿病前期人群中确定不同的子组.
- 为了在已识别的糖尿病前期亚组中比较葡萄糖代谢标志物.
- 为糖尿病前期患者提供个性化干预策略.
主要方法:
- 一项涉及哈萨克斯坦419名大学工作人员的跨界研究.
- 隐性类分析 (LCA) 用于根据心血管风险因素识别糖尿病前期子组.
- 在已识别的类别中比较葡萄糖代谢标志物 (禁食葡萄糖,OGTT,HOMA-IR,HOMA-β).
主要成果:
- 在研究人群中,糖尿病前期的患病率为43.4%.
- 确定了四个不同的糖尿病前期亚组:低风险,中度代谢风险,高心脏代谢风险和非常高的心脏代谢风险.
- 在各个类别中观察到葡萄糖代谢概况的显著差异,包括β细胞功能 (HOMA-β),其中第3类和第4类的β细胞功能障碍率更高.
结论:
- 在工作年龄的哈萨克斯坦人口中,糖尿病前期高度流行和异质.
- 使用易于获得的心血管风险因素,可以识别出具有明显葡萄糖特征的四个子组.
- 这些发现支持开发针对糖尿病前期的差异化,个性化预防策略.
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