腹膜透析相关的腹膜炎与所有原因死亡率和心血管死亡风险之间的关联:时间匹配的回顾性队列研究
Surapon Nochaiwong1,2,3, Kajohnsak Noppakun3,4, Manish M Sood5,6
1Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Medical sciences (Basel, Switzerland)
|November 24, 2025
概括
腹膜透析 (PD) 相关的腹膜炎显著增加了PD患者因任何原因死亡和心血管死亡的风险. 这凸显了减少腹膜炎和改善患者结果的干预措施的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 腹腔透析 (PD) 是一种常见的置换疗法.
- 与PD相关的腹膜炎仍然是一个重要的并发症.
- 有限证据证实了与PD腹膜炎相关的长期死亡风险.
研究的目的:
- 调查PD相关腹膜炎与所有原因死亡风险之间的关联.
- 为了检查PD相关的腹膜炎和心血管死亡之间的联系.
- 为了确定腹膜炎对PD患者死亡率的影响.
主要方法:
- 多中心,回顾性队列研究.
- 包括2006年至2020年期间开始PD的成年患者.
- 1:1匹配患有膜炎和没有膜炎的患者,其次是多变量Cox和竞争性风险模型.
主要成果:
- 一组3020名患者 (1510匹配对) 的队列,随访时间中位数为5.6年.
- 与PD相关的腹膜炎与所有原因死亡率 (HR 2.17) 和心血管死亡 (HR 2.90) 的风险显著增加有关.
- 根据年龄,性别,PD模式或并发症的子组分析,没有发现显著的相互作用.
结论:
- 与PD相关的腹膜炎是增加全因和心血管死亡率的独立风险因素.
- 这些发现强调了预防PD周周炎的重要性.
- 需要有针对性的干预措施来缓解腹膜炎后的不良结果.
相关概念视频
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
498
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
498
Peritoneal Dialysis III: Nursing Management
620
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
620
Peritoneal Dialysis I: Introduction and Procedure
2.1K
Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
2.1K
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
379
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
379
Acute Kidney Injury IV: Diagnostic Studies and Prevention
249
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
249
Dialysis
1.1K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.1K

