增加的NIS表达与三阴性乳腺癌的化学抵抗相关:与FOXA1活动的潜在联系
Grigory Demyashkin1,2, Anastasia Guzik1, Mikhail Parshenkov1
1Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, Moscow 125284, Russia.
Medical sciences (Basel, Switzerland)
|November 24, 2025
概括
在三阴性乳腺癌 (TNBC) 中,较高的/同载体 (NIS) 表达与对新辅助化疗反应较差有关. 这表明NIS可能是TNBC中化学抵抗的生物标志物,可能涉及FOXA1活动.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 医学研究 医学研究
背景情况:
- /同载体 (NIS) 对于甲状腺功能和放射性治疗至关重要.
- 包括乳腺瘤在内的甲状腺外组织中的NIS表达正在研究其功能和预后作用.
- 了解NIS调节及其与FOXA1等因素的联系,可能有助于促进乳腺癌治疗.
研究的目的:
- 调查/合载体 (NIS) 表达和三阴性乳腺癌 (TNBC) 新辅助化疗反应之间的相关性.
- 使用TCGA数据探索TNBC中NIS和FOXA1表达之间的关系.
主要方法:
- 对161名接受新辅助化疗治疗的TNBC患者的回顾性分析.
- 免疫组织化学评估NIS表达;残留癌症负担 (RCB) 尺度用于化疗反应评估.
- 统计分析包括肯德尔的相关性和TCGA数据集分析,用于NIS和FOXA1表达.
主要成果:
- 在69.5%的TNBC样本中发现了NIS免疫阳性.
- 较高的NIS表达与对新辅助化疗反应较差的显著相关 (较高的RCB指数).
- 与野生类型样本相比,在FOXA1突变的TNBC中观察到NIS mRNA表达的增加.
结论:
- 增加的NIS表达与接受新辅助化疗的TNBC患者的化学抵抗有关.
- 尼斯可以作为TNBC中化学抵抗的预测生物标志物,可能由FOXA1.1调解.
- 患者年龄和Ki-67之间的逆相关性表明年轻患者瘤生物学中的潜在差异.
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