关于艾滋病毒对COVID-19死亡,住院和ICU入院的影响的退出元分析
Lubna A Zar1, Shahd Hamran1, Izzaldin Alremawi1
1Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Medical sciences (Basel, Switzerland)
|November 24, 2025
概括
艾滋病毒感染者 (PLWH) 面临的COVID-19死亡率增加. 这项研究使用了退出元分析来确认艾滋病病毒.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- COVID-19大流行对艾滋病毒感染者 (PLWH) 的影响尚不清楚.
- 现有的元分析显示了有关HIV对COVID-19结果的影响的相互矛盾的结果.
- 需要确的证据来指导临床和公共卫生战略.
研究的目的:
- 为了最终更新关于艾滋病毒对COVID-19相关死亡率,住院和ICU入院的影响的证据.
- 用一种新的退出元分析技术进行强大的分析.
- 为医疗保健提供者和政策制定者提供明确的指导.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2024年1月.
- 包括元分析和观察性研究报告调整后的关联.
- 使用偏差调整的逆方差异性模型进行了更新的元分析.
主要成果:
- 更新后的元分析包括20个元分析和56个主要研究 (超过2700万参与者).
- 艾滋病毒与COVID-19死亡率 (aOR 1.43) 和ICU入院率 (aOR 1.49) 的增加有关.
- 退出元分析为增加死亡率提供了确的证据,但没有为ICU入院或住院提供确的证据.
结论:
- 艾滋病毒感染显著增加了COVID-19患者死亡的风险.
- 需要进一步的研究来澄清艾滋病毒对重症监护室入院和住院的影响.
- 这项研究提供了确的证据,支持在COVID-19期间针对PLWH的有针对性的干预措施.
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