生物钟受倦怠,荷尔蒙失调和循环节错位的影响:系统性审查
Alexandru Ungurianu1, Virginia Marina2
1Doctoral School of Biomedical Sciences, "Dunărea de Jos" University of Galati, 47 Str. Domnească, 800146 Galati, Romania.
Clocks & sleep
|November 24, 2025
概括
倦怠包括荷尔蒙和昼夜干扰,影响下丘脑-垂体-上腺 (HPA) 轴和像皮质醇这样的压力激素. 识别这些生物标记可以帮助更早地检测和干预倦怠.
科学领域:
- 时间生物学 时间生物学
- 内分泌学 在内分泌学.
- 职业健康 职业健康 职业健康
背景情况:
- 倦怠是一个日益关注的问题,被认为是一种心理社会和时代生物学的障碍.
- 它源于慢性压力,导致心理,身体和生理症状.
- 虽然已知心理社会因素,但包括皮质醇和黑激素在内的生物机制不太了解.
研究的目的:
- 系统地审查有关燃烧中荷尔蒙和昼夜调节失调的证据.
- 用医疗保健专业人员的探索性数据来补充现有文献.
主要方法:
- 对燃烧中的内分泌或昼夜生物标志物的同行评审研究进行系统审查.
- 在195名罗马尼亚临床医生的探索性观察分析中,他们使用了Maslach Burnout Inventory.
- 在一个子样本 (n=26) 中初步测量了早晨的唾液皮质醇.
主要成果:
- 综述发现了倦怠和改变HPA轴活动,日间皮质醇变异和不规则的黑色素分泌之间存在关联.
- 探索性数据显示,轮班工作的临床医生中,倦怠严重程度,身体症状和较高的早晨皮质醇之间的相关性.
- 初步的皮质醇数据表明与压力相关的激活,而不是完全的昼夜节律.
结论:
- 倦怠是一种系统性疾病,受内分泌和昼夜调节失调的影响.
- 改变的皮质醇和黑激素水平可以作为早期倦怠检测的客观指标.
- 时代生物学干预措施,如优化日程安排和光管理,可能是有益的.
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