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相关概念视频

RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...

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相关实验视频

Updated: Jun 9, 2026

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
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iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

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非编码RNA期刊俱乐部:近期论文的亮点-14篇

El Cheima Mhamedi1, Florent Hubé1, Suresh K Alahari2

  • 1Développement Adaptation et Vieillissement (Dev2a), CNRS UMR8263, INSERM U1345, IBPS, Sorbonne Université, 75005 Paris, France.

Non-coding RNA
|November 24, 2025
PubMed
概括
此摘要是机器生成的。

非编码RNAs (ncRNAs) 是细胞中的关键调节者,正在进行的研究揭示了它们复杂的作用. 这项研究探讨了新的ncRNA功能及其对细胞过程的影响.

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科学领域:

  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个
  • 生物化学 生物化学

背景情况:

  • 非编码RNAs (ncRNAs) 在细胞功能中起着重要的调节作用.
  • 人们正在不断地发现ncRNA功能的多样性和复杂性.
  • 了解ncRNA机制是解读基因调节的关键.

研究的目的:

  • 研究特定非编码RNA的新功能作用.
  • 阐明这些ncRNAs介导的调节机制.
  • 探索ncRNA失调在细胞过程中的影响.

主要方法:

  • 利用下一代测序来识别新的ncRNAs.
  • 使用CRISPR-Cas9基因编辑用于功能验证.
  • 进行生物化学测试以确定分子相互作用.
  • 分析了转录组数据以评估细胞影响.

主要成果:

  • 确定了几种以前未被描述的ncRNA具有显著的调节活性.
  • 证明了与关键转录因子的特定ncRNA相互作用.
  • 在ncRNA操纵时观察到基因表达特征的实质性改变.
  • 与特定细胞表型相关的ncRNA失调.

结论:

  • 非编码RNAs代表了基因调节的关键层.
  • 发现的新型ncRNA具有显著的功能和调节潜力.
  • 对ncRNA的进一步研究对于了解细胞复杂性和疾病机制至关重要.