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鱼类面临的双重挑战:温暖和水生系统中药物的联合压力
Tiago Lourenço1,2, Maria João Rocha1,2, Eduardo Rocha1,2
1Group of Animal Morphology and Toxicology, Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
Journal of xenobiotics
|November 24, 2025
概括
水温上升会放大鱼类中的药物毒性,影响它们的健康和行为. 本次审查强调,迫切需要了解气候变化和毒品污染对水生生态系统的综合影响.
科学领域:
- 环境毒理学环境毒理学
- 水生生态学 水生生态学
- 气候变化科学 气候变化科学
背景情况:
- 水生生态系统面临着气候变化和制药污染带来的越来越大的威胁.
- 鱼类作为外热生物,容易受到水温上升 (预计2-5°C) 和制药污染物 (ng·L-1~μg·L-1).
研究的目的:
- 综合关于鱼类中变暖和药物暴露的相互作用影响的实验证据.
- 确定研究缺口,并为未来的生态风险评估提供信息.
主要方法:
- 自2005年以来发表的39项同行评审研究的叙述性审查.
- 对药物对鱼类生理学和不同温度下的行为影响的实验数据的分析.
主要成果:
- 高温往往会加剧制药毒性,影响鱼类的氧化应激,新陈代谢,繁殖和行为.
- 变暖加速了抗生素的新陈代谢,缩短了药物的半衰期.
- 激素和抗真菌药物与温度相互作用,破坏鱼类的繁殖和性别决定.
- 神经精神药物在温暖的条件下显示出增加的生物积累和行为变化.
- 疼痛缓解剂在氧化应激上与热的协同作用已被注意到,但研究不足.
结论:
- 综合变暖和制药污染对鱼类健康和水生生态系统构成重大风险.
- 在慢性暴露,早期发育,生态相关的温度和研究不足的药物类别方面存在研究缺口.
- 综合方法对于预测气候变化中的生态风险至关重要.
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