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Updated: Jan 10, 2026

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没有卡尔西的甲状腺髓性癌:一个将终端骨干体与瘤进化联系起来的案例
Ion Prisneac1, Abigail I Wald2, Chelsea Bragg1
1Department of Pathology, Anatomy and Laboratory Medicine, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA.
概括
甲状腺核癌 (MTC) 是罕见的. 这一案例探讨了终末体残骸与MTC发育之间的潜在联系,为甲状腺瘤起源提供了新的见解.
科学领域:
- 内分泌学 在内分泌学.
- 手术病理学手术病理学
- 在瘤学瘤学.
背景情况:
- 甲状腺髓性癌 (MTC) 是甲状腺C细胞的神经内分泌瘤,通常产生素.
- 阴性卡尔西托尼MTC是一种罕见的变体,缺乏高血清卡尔西托尼.
- C细胞起源于内皮和终末支骨体,而不是以前认为的神经.
研究的目的:
- 为了研究终端枝状体 (UBB) 遗留物在卡尔西托尼阴性MTC的发展中的潜在作用.
- 探索从UBBs到C细胞增生/髓小癌 (CCH/MMC) 的瘤进展的假设,随后到MTC.
- 分析一个独特的病例,呈现UBB残留物,CCH/MMC和素阴性MTC与混合表型.
主要方法:
- 案例报告和文献综述.
- 免疫组织化学 (IHC) 对于素的表达.
- 使用ThyroSeq®对MTC分类器状态进行分子分析.
主要成果:
- 这项研究呈现了一例独特的素阴性MTC病例,该病例发生在一名58岁的男性身上,同时存在UBB残留物和CCH/MMC.
- 虽然CCH/MMC区域通过IHC表达色素,但主要的MTC瘤是色素阴性.
- ThyroSeq®确定了UBB残留物,CCH/MMC和MTC作为MTC分类器阳性.
结论:
- UBB残留物可以作为CCH/MMC和素阴性MTC的前体.
- 这些发现支持从UBBs到MTC的潜在顺序性瘤进展.
- 这一案例凸显了甲状腺瘤的复杂起源,包括混合毛囊和髓类型.
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