超脂血症与更高的肥胖,代谢综合征和肝功能障碍有关,主要影响男性:巴西南部的一项研究
Késia Zanuzo1,2, Márcia Fernandes Nishiyama2, Eloá Angélica Koehnlein3
1Postgraduate Program in Biosciences and Health, State University of Western Paraná (UNIOESTE), Cascavel 85819-110, Brazil.
概括
在成年人中,高血清费里丁 (SF) 与肥胖,代谢问题和肝脏问题有关,特别是在男性中. 升高的SF可能有助于识别与代谢功能障碍相关的脂肪性肝病 (MASLD).
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
背景情况:
- 血清费里丁 (SF) 反射铁稳态,是急性相反应剂.
- 在肥胖症中观察到改变的SF水平,影响代谢和肝脏健康.
- 了解SF水平与代谢/肝脏健康之间的关系对于临床实践至关重要.
研究的目的:
- 为了比较正常与高血清费里 (SF) 水平的成年人的身体组成,代谢概况,肝脏变化和饮食模式.
- 调查SF水平与肥胖,代谢障碍和肝脏健康指标之间的关联.
- 在成年人群中确定增加SF的预测因子.
主要方法:
- 使用113名成年人的二次数据进行横截面研究.
- 参与者分为正常或高SF组.
- 评估社会经济,人体测量,血压,饮食,生化和肝脏参数;进行统计分析.
主要成果:
- 高SF的成年人更常见的是肥胖的男性,身体脂肪百分比较高,心血管风险较高,以及代谢障碍 (葡萄糖升高,甘油三,胰岛素耐药性,高血压,代谢综合征).
- 肝酶 (ALT),尿酸和脂肪酸指标的升高在高SF组中更为常见.
- 后勤回归表明,男性和体脂百分比增加的个体具有更高的SF升高的可能性;饮食没有显著影响SF水平.
结论:
- 在成年人中增加的SF与肥胖有关,特别是在男性中,并与胰岛素抵抗,代谢综合征和肝功能障碍有关.
- SF可以作为一种有价值的生物标志物来诊断代谢功能障碍和与肥胖相关的肝脏疾病,如MASLD.
- 对用于代谢和肝病诊断的铁生物标志物的进一步研究是有必要的.
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