植物性饮食可以缓解高血压中的分子肺异常
Rami Salim Najjar1,2, Jaishree Jagirdar3, Andrew T Gewirtz1
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Advances in respiratory medicine
|November 24, 2025
概括
植物性饮食 (PBD) 可以改善患有高血压的雌性大鼠的肺部异常. 这种饮食对内皮氧化合成酶 (eNOS) 有积极的影响,并减少亲纤维细胞信号传递,这表明对肺高血压的潜在益处.
科学领域:
- 心血管研究研究心血管研究
- 肺部医学 肺部医学
- 营养科学 营养科学
背景情况:
- 基本高血压增加了肺高血压 (PH) 的风险,特别是在女性中.
- 植物性饮食 (PBD) 对高血压相关的肺部异常的影响仍未得到充分研究.
研究的目的:
- 研究PBD对雌性自发高血压大鼠 (SHRs) 肺中的分子变化的影响.
- 为了确定PBD是否可以预防或逆转高血压引起的肺部异常.
主要方法:
- 雌性Wistar京都老鼠和SHRs从4周大开始被食控制饮食或PBD.
- 分析了肺组织的蛋白质表达和组织学变化.
- 一组SHR在28周转换为PBD以评估逆转效应.
主要成果:
- 对照饮食中的SHR显示,与正常压力大鼠相比,肺内皮氧化合成酶 (eNOS) 减少.
- 消费PBD可以防止并逆转SHR中eNOS的下降.
- 在SHR中,PBD摄入减弱了细胞外信号调节激酶 (ERK) 1/2酸化和转化生长因子-β1 (TGF-β1) 激活的增加.
结论:
- 一种PBD有利于调节高血压引起的肺内皮质,上皮结和亲纤维信号传递中的肺分子异常.
- 这些发现表明,PBD可能有助于管理与高血压相关的肺部疾病.
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