修改支持性护理药物的效果与珀图祖马布,特拉斯图祖马布和塔坎抗癌药物的联合治疗
Mina Takagi1, Shinichiro Maeda1,2, Makiko Maeda1,3
1Laboratory of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita 565-0871, Osaka, Japan.
在乳腺癌化疗期间停止服用抗热止痛药 (珀图祖马布,特拉斯图祖马布,多塞塔克塞尔/帕克利塔克塞尔) 并没有改变整体副作用频率. 然而,症状的严重程度,比如感觉很热,增加了.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳腺癌化疗方案,如PHD (珀图祖马布,特拉斯图祖马布,多塞塔克塞尔) 和PHP (珀图祖马布,特拉斯图祖马布,帕克利塔克塞尔) 与副作用有关.
- 管理这些副作用的最佳支持性护理策略尚未确定.
研究的目的:
- 通过停止服用抗发烧止痛药来修改支持性护理对接受PHD或PHP化疗的患者副作用的发生和严重性的影响进行调查.
- 评估抗热止痛药在管理化疗引起的不良事件中的临床意义.
主要方法:
- 对76名接受PHD或PHP化疗的患者的不良事件的回顾性分析.
- 支持性护理改变之前和之后的副作用频率和严重程度的比较,特别是停止服用抗发烧止痛药.
主要成果:
- 在 (45.5%) 和 (44.2%) 停止服用抗发烧止痛药之前,没有观察到不良反应的总体频率有显著差异.
- 两组之间在不良反应的严重程度上没有发现显著差异.
- 在修改了支持性护理后,人们注意到症状的严重程度增加,例如感觉很热,发烧和脸红.
结论:
- 停止服用抗发烧止痛药作为支持性护理对副作用的总体频率的影响很小,但可能会增加特定症状的严重程度.
- 修改支持性护理,包括抗热止痛药,可能会导致需要医疗干预的副作用.
- 需要进一步的研究来分析预测症状发展的风险因素,并重新考虑前期治疗策略.
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