衰弱的老年人使用药物:一个范围审查
Rishabh Sharma1, Tanaya Sharma1, Brent McCready-Branch1
1School of Pharmacy, University of Waterloo, 10 Victoria St S A, Kitchener, ON N2G 1C5, Canada.
Pharmacy (Basel, Switzerland)
|November 24, 2025
概括
药物使用显著增加了脆弱的老年人的健康风险. 这次审查发现,在这个脆弱人群中,多药和潜在不合适药物 (PIM) 的比例很高.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 老年人的虚弱是不良健康结果的重要危险因素.
- 药物使用是导致脆弱个体脆弱的一个主要因素.
研究的目的:
- 在初级保健机构内探索老年人虚弱的药物使用模式.
- 调查潜在不合适药物 (PIMs),多药和药物坚持的流行情况.
- 了解药物使用在脆弱的老年人中药物不良事件中的作用.
主要方法:
- 根据Arksey和O'Malley的指导方针进行了范围审查,并补充了PRISMA-ScR.
- 在主要数据库 (EMBASE,PubMed,Scopus,CINAHL,国际制药摘要) 进行文献搜索,截至2023年11月.
- 包括专注于有虚弱的老年人 (≥65岁) 的研究,评估药物使用.
主要成果:
- 包括来自39个国家的223项研究,脆弱性患病率从0.9%到89.2%不等.
- 多药性 (5-9种药物) 和超多药性 (≥10种药物) 非常普遍,比例从1.3%到96.4%.
- 可能不合适的药物 (PIM) 患病率差异很大,从2.4%到95.9%.
结论:
- 药物使用,包括多药和PIM,对脆弱的老年人来说带来了重大挑战.
- 需要进一步的研究才能充分理解药物管理与脆弱性之间的复杂关系.
- 针对脆弱的老年人药物使用的干预措施对于改善健康结果至关重要.
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