伪造表面的等离子极光子和表面增强的拉曼光谱双模式检测多个生物标志物在汗水中的
Zhaoxian Chen1,2, Shiyi Zhou1,2, Li Wang3
1College of Physics, Center of Quantum Materials and Devices, Chongqing University, Chongqing 401331, China.
Analytical chemistry
|November 24, 2025
概括
这项研究引入了一种双模式传感器,该传感器结合了伪造表面等离子极子子 (spoof-SPPs) 和表面增强拉曼光谱 (SERS) 来检测多个汗水生物标志物. 这种新的方法准确地识别了生物标记物比例,克服了单个技术的局限性.
科学领域:
- 电磁检测检测 电磁检测 电磁检测
- 生物标志物传感器传感器
- 纳米技术纳米技术
背景情况:
- 表面增强拉曼光谱 (SERS) 和伪造表面等离子体极子子 (spoof-SPPs) 是先进的电磁检测技术.
- 当前的方法在同时检测不同比例的多个生物标志物时面临挑战.
研究的目的:
- 开发一种新型的双模式传感器,集成Spoof-SPP和SERS,用于同时检测多个汗水生物标志物.
- 在复杂的生物样本中克服单个Spoof-SPP和SERS技术的局限性.
主要方法:
- 一个阿基米德螺旋Cu补丁的制造与一个银 (Ag) 纳米珊瑚表面集成.
- 使用阿基米德螺旋Cu补丁作为Spoof-SPPs传感器进行高灵敏度检测.
- 使用Ag纳米珊瑚表面用于SERS检测,提供额外的定量信息.
主要成果:
- 伪造SPPs传感器对目标生物标志物表现出高灵敏度.
- 根据特征性峰值强度,SERS提供了关于生物标志物比例的补充数据.
- 双模式传感器准确地识别了100nM的汗水中的肌素和尿素的不同体积比.
结论:
- 新型伪造SPP和SERS双模式检测有效地解决了多目标传感和定量分析的局限性.
- 这种综合方法显示出在复杂的生化系统中进行准确可靠的传感的巨大潜力.
- 该技术在先进的诊断和监测中提供了有前途的应用.
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