导管设计中的3D打印创新,以减少导管相关的感染:一个范围审查
Roopa Gayathri Koduganti1, Karthik Prabhu1, Aadil Bashir1
1Department of Pharmacy Practice, Manipal College of Pharmaceutical Science, Manipal Academy of Higher Education, Manipal, India.
Journal of biomaterials science. Polymer edition
|November 24, 2025
概括
3D打印的导管提供了创新的解决方案,通过实现个性化的设计和有针对性的药物输送来预防导管相关感染 (CAI). 克服监管和试验障碍是它们广泛采用的关键,以改善患者的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 预防传染病 预防传染病
- 医疗设备创新 医疗设备创新
背景情况:
- 导管相关感染 (CAI) 由于生物膜和抗菌素耐药性,造成了严重的医疗负担.
- 目前的预防策略,包括涂层和杀菌,显示长期有效性的局限性.
- 传统的导管设计给感染控制带来了固有的挑战.
研究的目的:
- 进行对用于预防感染的导管设计创新的范围审查.
- 确定导管开发技术进步的关键领域.
- 评估3D打印在解决CAI方面的潜力和挑战.
主要方法:
- 一个系统的范围审查,遵守PRISMA-ScR指南.
- 在PubMed,Scopus和谷歌学者中进行文献搜索,产生了545个记录.
- 对36项精选的同行评审研究进行分析,重点关注导管创新.
主要成果:
- 确定了8个创新领域,包括3D打印,抗菌涂层和人工智能辅助设计.
- 3D打印的导管展示了个性化几何形状,有针对性的抗菌素释放和增强生物相容性的潜力.
- 临床翻译受到方法不一致,长期数据不足和监管障碍的阻碍.
结论:
- 3D打印为导管设计和CAI预防提供了一种变革性的方法.
- 跨学科的合作和标准化的评估对于推进这些技术至关重要.
- 强大的监管框架是必要的,以弥合实验室创新和临床应用之间的差距.
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