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患有泛性的儿童的调控T细胞:一个病例控制研究

Khaled Saad¹, Eman F Gad², Samaher Taha²

¹Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. khaled.ali@med.au.edu.eg.

European journal of pediatrics

|November 24, 2025

概括

新诊断为全性的儿童显示调控T细胞 (Tregs) 减少,免疫细胞水平发生变化. 这种免疫失调可能会导致的病理生理学,这表明Tregs恢复是潜在的治疗方法.

科学领域:

免疫学免疫学免疫学
神经学神经学
儿科儿科儿科

背景情况:

新出现的证据将免疫失调,特别是调节性T细胞 (Tregs) 与病原体联系起来.
关于儿科泛性的Tregs概况的数据有限.
在儿科中报告了促炎性细胞因子升高和Tregs缺乏.

研究的目的:

为了比较埃及儿童的外围Tregs水平和免疫特征,新诊断的全身性与健康对照.
为了研究在未使用过毒品的儿童中疾病发病时的免疫特征.

主要方法:

一个病例控制研究,涉及45名患有的儿童和45名健康的对照.
使用多色流细胞计量对Tregs和免疫标记物的量化.
通过ELISA测量血清细胞因子 (IL-10,IL-6,IFN-γ,TNF-α,IL-1β).

主要成果:

与对照组相比,患有的儿童的Tregs百分比明显较低 (1.95% ± 0.7%),比对照组 (3.1% ± 0.9%,p < 0.001).
在组中观察到减少的CD4+T细胞和增加的CD8+T细胞,B细胞和NK细胞.
在患有的儿童中发现IL-10和促炎细胞因子 (IL-1β,TNF-α,IFN-γ,IL-6) 的水平升高.

结论:

免疫失调,包括降低Tregs和改变淋巴细胞分布,与儿童普遍性有关.
双重的促炎/抗炎细胞因子可能在病理生理学中起作用.
结果支持探索针对Tregs恢复潜在疾病修饰的免疫调节策略.

关键词:

孩子孩子孩子孩子孩子孩子细胞因子 (cytokines) 是一种细胞因子.,一般化的.免疫系统疾病免疫系统疾病监管性T细胞是什么意思

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