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激发性磁刺激增加了半球间抑制:一个药理学和TMS-EEG研究

Yazhen Han¹, Zhimin Huang¹, Yujun Wang¹

¹Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, 2318 Yuhangtang Road, Yuhang District, Hangzhou, Zhejiang 311121, China.

Cerebral cortex (New York, N.Y. : 1991)

|November 24, 2025

概括

重复的横磁刺激 (rTMS) 增强了半球间抑制,通过半球间信号传播 (ISP) 测量. 这种效应是由GABAB受体活性调节的,为优化rTMS疗法提供了洞察力.

科学领域:

神经科学是一个神经科学.
神经生理学神经生理学
精神病学研究精神病学研究

背景情况:

半球间信号传播 (ISP) 涉及GABAB受体介导的抑制,并影响大脑连接.
重复的横磁刺激 (rTMS) 改变了大脑的连接,但它对ISP的影响还不太清楚.

研究的目的:

调查rTMS对ISP的影响.
检查GABAB受体神经传递在介导ISP中rTMS诱导的变化的作用.
用TMS引起的马振荡来确定皮层内抑制的可靠指标.

主要方法:

使用TMS-EEG联合注册来测量ISP.
在rTMS之前使用巴克洛芬 (GABAB激动剂) 预治疗.
应用刺激性rTMS (>5 Hz) 和分析TMS引起的马振荡.

主要成果:

刺激性rTMS增加了半球间抑制,如ISP所示.
巴克洛芬预治疗减少了因rTMS引起的ISP增加,这表明GABAB受体参与.
由TMS引起的马振荡可靠地表明皮质内抑制.

结论:

rTMS调节半球间抑制,其作用受到GABAB受体活性的影响.
这些发现澄清了半球间连接的RTMS机制.
结果可能会为针对精神疾病的优化rTMS协议提供信息.

关键词:

对于GABA来说,这是一个很好的选择.提供服务提供商 ISP ISP ISP 在TMSMS中使用.这就是TMS-EEG.玛玛玛是一个

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相关概念视频

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).