脊柱微型旁路器 (iStent) 的长期有效性:对玻璃眼和眼睛高血压的3年真实世界数据
Stafford Sansome1,2, Ujjwal Banerjee3, Benjamin Griffin1,2
1King's College Hospital NHS Foundation Trust, London, UK.
International ophthalmology
|November 24, 2025
概括
与白内障手术相结合的iStent®注射显著降低了眼内压力 (IOP) 和在三年内对玻璃眼病患者的药物使用. 这种组合疗法表现出良好的安全性,需要进行几次随后的玻璃眼手术.
科学领域:
- 眼科医生 眼科 眼科
- 视光眼管理 视光眼管理
- 手术创新 在外科创新.
背景情况:
- 失控的眼内压力 (IOP) 是黄眼病进展的主要危险因素.
- 有效的IOP管理通常需要多种药物,这可能导致不良的坚持和副作用.
- 最少侵入性玻璃眼手术 (MIGS) 提供了医疗治疗的替代方案或辅助方案.
研究的目的:
- 评估iStent注射®与白内障手术相结合的长期有效性和安全性.
- 为了评估持续的眼内压力降低和药物负担超过3年.
- 分析不同疾病严重程度的多样化眼患者队列的结果.
主要方法:
- 追溯性,单臂,多外科医生研究设计.
- 包括464只眼睛,尽管服用药物,但患有症状性白内障和不受控制的IOP.
- 评估IOP,药物使用,安全事件和累计成功率在3年的随访.
主要成果:
- 平均内血压下降了19.1%,从手术前的18.3 mmHg降至3年后的14.8 mmHg (P < 0.001).
- 平均药物使用量从2.49降至1.84剂,有24%的眼睛在3年后不再使用药物.
- 3年后,累计成功率为37% (完全) 和67% (合格);没有观察到危及视力的并发症.
结论:
- iStent注射®与发泡乳化相结合,可在3年内显著和持续地降低内血压.
- 这种综合方法有效地减少了青光眼患者的药物负担.
- 该程序具有优异的安全性,最大限度地减少了对额外的绿眼瘤手术的需求.
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