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光学连贯断层扫描血管造影在评估眼表面状瘤对局部免疫治疗的反应

Hamidreza Ghanbari¹, Ahmad Masoumi², Mahsan Samadi¹

¹Department of Ophthalmology, Farabi Eye Hospital, School of Medicine, Tehran University of Medical Sciences, Qazvin Sq, Tehran, Iran.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

|November 24, 2025

概括

局部干扰素α-2b (IFN-α2b) 有效治疗眼表面状瘤 (OSSN). 光学连贯断层扫描血管造影 (OCTA) 显示表面血管密度和直径显著下降,表明治疗反应.

科学领域:

眼科医生眼科眼科
在瘤学瘤学.
医疗成像医学成像

背景情况:

眼表面状瘤 (OSSN) 是一种前恶性或恶性上皮瘤.
局部干扰素α-2b (IFN-α2b) 是一种常见的OSSN治疗方法.
评估治疗疗效需要监测瘤血管性.

研究的目的:

评估在局部IFN-α2b治疗OSSN.N.期间光学一致性断层扫描血管学 (OCTA) 参数的变化.
确定OCTA是否可以有效监测OSSN患者的治疗反应.

主要方法:

35名OSSN患者接受了局部IFN-α2b.
进行了眼科检查和裂纹灯摄影.
OCTA成像在基线,治疗期间和解析后捕捉了眼睛表面血管.
测量了表面和深层血管密度 (VD),血管长度密度 (VLD) 和血管直径指数 (VDI).

主要成果:

平均瘤面积在治疗期间从20.7mm2减少到15.1mm2.
表面VD显著下降,从36.3%降至30.5% (P<0.05).
表面VDI显著下降,从1.87降至1.74 (P<0.05).
在深血管参数或VLD中没有发现显著变化.

结论:

在医疗治疗期间,OCTA是评估OSSN血管变化的宝贵工具.
表面VD和VDI的下降可能作为局部IFN-α2b治疗成功反应的指标.

关键词:

前部部分的前部部分.国际货币基金组织 IFN IFN 八国合作组织 (OCTA)这是一个OSSNN.眼睛表面的瘤是什么

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