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在急性初级角关闭中光盘胀:相关因素和纵向OCT变化

Garam Shin¹, Joo Eun Ha¹, Sung Uk Baek²

¹Department of Ophthalmology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, South Korea.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

|November 24, 2025

概括

在急性初级视角闭眼眼中视觉盘胀与延迟治疗和较大的瞳孔有关. 受影响的眼睛表现出持续的结构损失,尽管控制了IOP,这表明需要早期干预.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
视网膜成像视网膜成像

背景情况:

急性初级闭角光眼 (AACG) 可能导致视盘胀 (ODS).
了解与ODS相关的因素及其对视网膜结构的长期影响对于患者管理至关重要.
光学连贯断层扫描 (OCT) 允许详细分析视网膜神经纤维层 (RNFL) 和质细胞内状层 (GCIPL) 厚度.

研究的目的:

在AACG中确定与ODS相关的临床因素.
评估使用OCT在ODS眼睛治疗后的RNFL和GCIPL的纵向结构变化.
为了比较具有和没有ODS的眼睛之间的稀疏率.

主要方法:

对102个AACG眼睛进行了回顾性研究,这些眼睛接受了激光 iridotomy (LI) 治疗,并进行了至少两年的跟踪.
根据光盘外观和OCT发现,将眼睛分为ODS和对照组.
用于因子分析的多变量逻辑回归;在六个时间点测量RNFL和GCIPL的OCT;计算和比较短期和长期稀释率.

主要成果:

在42只眼睛中存在ODS,与较大的瞳孔直径 (OR=15.23) 和较长的症状持续时间 (OR=2.03) 相关.
在ODS眼中,最初的RNFL变厚,随后持续变薄,而GCIPL的厚度持续下降.
长期的RNFL稀释 (6个月-2年) 在ODS眼睛 (-2.86微米/年) 与对照中的显著更大 (-0.77微米/年) (P=0.005);GCIPL稀释也更大 (P=0.006).

结论:

在AACG中,ODS与延迟治疗和较大的瞳孔有关,这表明缺血压力增加.
尽管IOP控制,ODS眼睛在RNFL和GCIPL中经历了显著的,持续的结构损失.
早期干预和量身定制的后续策略对于使用ODS来管理AACG至关重要,以减轻结构损伤.

关键词:

急性闭角光眼 (Glaucoma) 是一种急性闭角光眼.相关因素相关因素纵向研究是一项纵向研究.视觉盘的胀视觉盘的胀光学连贯性断层扫描技术.

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