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肝脏疾病中的deubiquitinases:从机制到向治疗

Zhenge Zhang^1,2, Wanli Duan^1,3, Yixiang Wang¹

¹School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, China.

Science China. Life sciences

|November 24, 2025

概括

脱基酶 (DUB) 在脂肪肝和癌症等肝脏疾病中至关重要. 抑制DUBs对针对这些主要肝脏疾病的向治疗有希望.

科学领域:

生物化学生物化学
分子生物学分子生物学
肝病学肝病学是一种肝病学.

背景情况:

主要的肝病,包括脂肪肝,肝炎和肝细胞癌 (HCC),对全球健康构成重大挑战.
无素-蛋白酶系统 (UPS) 调节蛋白质降解,而双素酶 (DUB) 控制了无素化/脱素化平衡.
DUB失调与慢性肝病 (CLD) 和HCC有关,突出显示了它们的致病作用.

研究的目的:

审查DUBs导致肝脏疾病的机制,例如与代谢功能障碍相关的脂肪性肝病 (MASLD),病毒性肝炎,肝纤维化和HCC.
总结DUB抑制剂在治疗主要肝脏疾病中的治疗潜力.
为肝脏疾病的研究和治疗策略提供基础.

主要方法:

文献综述侧重于DUBs在肝病病原发生中的作用.
对研究分析研究的研究分析DUBs在MASLD,病毒性肝炎,纤维化和HCC.
检查DUB抑制剂作为治疗剂的临床前和临床数据.

主要成果:

在各种肝病态的发展和进展中,DUBs扮演着多方面的角色.
针对特定DUBs的向抑制在肝病的临床前模型中显示出显著的治疗疗效.
小分子DUB抑制剂为选择性和低副作用的治疗提供了一个有希望的途径.

结论:

DUBs是肝脏疾病发展的关键调节者,使它们成为有吸引力的治疗点.
DUB 抑制剂代表了对 MASLD,病毒性肝炎,纤维化和 HCC 新型治疗的有希望的策略.
对DUB的进一步研究将促进我们对主要肝脏疾病的理解和治疗.

关键词:

慢性肝脏疾病慢性肝脏疾病必须有这些东西.肝细胞癌是肝细胞癌.有针对性的治疗.

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