相关实验视频

Updated: Jan 6, 2026

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
05:55

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System

Published on: December 21, 2019

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通过SWI/SNF复杂介导的染色质重塑促进B型肝炎病毒ccccDNA转录

Xiaoxue Yuan1,2,3,4, Wenqian Geng5,6,7,8, Jiyin Wang5,6,7,8

  • 1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. yuanxiaoxue1@ccmu.edu.cn.

Science China. Life sciences
|November 24, 2025
PubMed
概括

哺乳动物SWI/SNF染色体重塑剂,包括BRG1 (SMARCA4) 和BRD9,对于乙型肝炎病毒 (HBV) 协同封闭圆形DNA (cccDNA) 转录至关重要. 准这些复合体为慢性HBV感染的功能治愈提供了潜在的战略.

关键词:
这就是HBV的ccDNA.在 SWI/SNF 复合体中.染色质可访问性 染色质可访问性药理上的抑制药理上的抑制.转录活动转录活动.

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