在炎症性肠道疾病中粘素签名的临床意义:对其表达模式,多态和翻译后修改的系统性审查
Wout Arras1,2, Baptiste Oosterlinck1,2, Julie Gassman1,2
1Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
粘素在炎症性肠病 (IBD) 中发生变化,表达变化,基因变异和影响肠道屏障的修改. 这些发现突出了粘蛋白作为IBD相关屏障功能障碍的潜在生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠粘膜屏障在炎症性肠病 (IBD) 病理生理学中至关重要.
- 粘素,高度糖化蛋白质,是这一屏障的关键组成部分,影响其完整性.
- 目前对IBD中的粘蛋白的研究缺乏关于表达,多态和修饰的共识.
研究的目的:
- 系统地审查IBD患者的粘素变化.
- 分析转录,翻译和后翻译层面的变化.
- 评估粘膜在IBD肠道屏障功能障碍中的作用.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索.
- 包括1993年2月至2025年1月间发表的研究.
- 对69篇关于IBD中的粘素变异的合格文章的分析.
主要成果:
- 在RNA和蛋白质水平上对MUC1,MUC5AC,MUC6的升调;在炎症的粘膜中,MUC12在RNA水平下调.
- MUC2在蛋白质水平上持续下调,mRNA没有变化;几个粘膜中的多态性与IBD易感性有关.
- 观察到MUC1/MUC2的低糖化和MUC2硫化减少.
结论:
- 素在IBD的病理生理学中起着重要作用.
- 粘蛋白表达的变化,遗传学和修改有助于屏障功能障碍.
- 蛋白显示出作为评估IBD肠道屏障完整性的生物标志物的潜力.
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