避免/限制食物摄入的表型的流行,特征和遗传结构
Ludvig Daae Bjørndal1,2, Elizabeth C Corfield2,3,4, Laurie J Hannigan2,3,4
1PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
JAMA pediatrics
|November 24, 2025
概括
避免/限制性食物摄入 (ARFI) 障碍影响6.3%的儿童,持续的病例与发育困难有关. 基因分析发现了两个显著的位点和ADCY3的关联,突出了早期支持和对ARFI进一步研究的需要.
科学领域:
- 儿科健康 儿科健康
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 避免性/限制性食物摄入 (ARFI) 障碍的特点是食物摄入量有限,但其发育轨迹和遗传因素不明.
- 对ARFI发育特征和病因学的有限知识阻碍了研究,预防和干预工作.
研究的目的:
- 在基于人口的样本中估计ARFI表型的流行率.
- 在整个童年期内检查ARFI儿童的发育特征.
- 通过全基因组关联分析,研究ARFI的遗传结构.
主要方法:
- 利用了挪威母亲,父亲和儿童队列研究 (MoBa) 对1999-2009年出生儿童的数据.
- 根据母亲在3岁和8岁时报告的症状确定了ARFI表型,并根据持久性和临床意义对其进行分类.
- 采用全基因组方法来评估遗传性,进行关联分析,并量化与其他表型的遗传相关性.
主要成果:
- 广泛ARFI的患病率为32.1% (暂时17.7%,新兴8.4%,持久6.0%);临床ARFI的患病率为6.3% (持久1.8%).
- 与对照组相比,患有持续性ARFI的儿童表现出更多的发育困难.
- 确定了ARFI的两个全基因组显著位置,临床ARFI与ADCY3基因有显著的关联 (P = 3.03 × 10-8).
结论:
- ARFI在一般儿科患者中普遍存在,并与增加的发育困难有关.
- 调查结果强调,需要为患有ARFI的儿童提供全面的支持干预.
- 这项研究促进了对ARFI遗传基础的理解,为未来的研究和治疗策略提出了潜在的目标.
相关概念视频
Anorexia Nervosa
844
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
844
Bulimia Nervosa
633
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
633
Social Anxiety Disorder
386
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
386
Personality Disorders: Narcissistic and Avoidant
637
Narcissistic and avoidant personality traits represent two contrasting patterns of behavior that significantly influence social interactions and self-perception. While individuals with narcissistic disorder seek admiration and validation, individuals with avoidant personality disorder withdraw due to fear of judgment.
Characteristics of Narcissistic Personality Disorder
Narcissistic individuals exhibit an inflated sense of self-importance and an excessive need for admiration. They are often...
Characteristics of Narcissistic Personality Disorder
Narcissistic individuals exhibit an inflated sense of self-importance and an excessive need for admiration. They are often...
637
Taste Buds and Receptors
4.5K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
4.5K
Conditioned Taste Aversion
496
Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
A notable characteristic of conditioned taste aversion is that it often requires only a single...
A notable characteristic of conditioned taste aversion is that it often requires only a single...
496


