与急性登革热感染相关的神经事件
Liang En Wee1,2,3, Wei Zhi Tan1, Jo Yi Chow4
1Communicable Diseases Agency, Singapore.
JAMA neurology
|November 24, 2025
概括
登革热病毒 (DENV) 感染显著增加了急性神经事件的风险,包括记忆丧失和运动障碍,特别是在老年人中. 虽然整体的过度负担很小,但对这些并发症的监测至关重要.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 全球登革热病毒 (DENV) 感染的发病率正在上升,需要更好地估计相关的神经并发症.
- 对DENV感染后神经事件负担的基于人口的数据有限.
研究的目的:
- 评估与未感染个体相比,在DENV感染后成年人中神经事件的风险和过度负担.
- 确定与DENV感染相关的特定神经事件类型和风险因素.
主要方法:
- 在新加坡使用国家登记册进行了回顾性,基于人口的队列研究.
- 在2017-2023年期间,与65207名DENV感染的成年人进行了比较,并与1616865名未感染的比较者进行了比较.
- 通过医疗保健索赔确定的神经事件;感染后30-90天分析风险.
主要成果:
- 在30天内,DENV感染与急性神经事件 (aOR 9.69) 的几率明显增加.
- 对记忆丧失 (aOR 3.19),运动障碍 (aOR 7.10) 和其他神经事件 (aOR 14.32) 观察到更高的几率.
- 记忆丧失和运动障碍的风险增加在60岁以上的个体和感染DENV血清型3的人群中显著增加.
结论:
- DENV感染增加了急性神经事件的风险,尽管整体过度负担很小.
- 老年人 (≥60岁) 和患有DENV血清型3感染的人需要更密切地监测神经系统并发症.
- 这些发现强调了识别和管理DENV感染的神经系统后果的重要性.
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