艾滋病毒感染者心血管风险增加:与冠状动脉化和内皮功能障碍的相关性
Anas Ismail1, Idris Garba2, Abbas Rabiu Muhammad1
1Department of Radiology, Faculty of Clinical Sciences, Bayero University, Kano, Nigeria.
AIDS (London, England)
|November 24, 2025
概括
尼日利亚艾滋病毒感染者 (PWH) 的冠状动脉疾病 (CAD) 负担明显高于艾滋病毒阴性个体. 在PWH中,这种心血管风险的增加需要将查和预防整合到HIV护理中.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 冠状动脉疾病 (CAD) 在全球范围内构成了重大健康挑战.
- 艾滋病毒感染者 (PWH) 可能因慢性炎症和抗逆转录病毒疗法 (ART) 等因素而患上加速心血管疾病.
- 了解尼日利亚北部等特定地区的PWH中的CAD负担对于有针对性的干预至关重要.
研究的目的:
- 评估艾滋病毒感染者 (PWH) 的CAD的患病率,严重程度和模式.
- 研究PWH中CAD与代谢综合征,炎症和内皮功能障碍之间的关联.
- 为了比较PWH和HIV阴性个体之间的心血管风险因素.
主要方法:
- 一项涉及72个PWH和72个匹配的HIV阴性对照的比较横截面研究.
- 评估包括人口统计,代谢参数,病毒载量,臂动脉流介导扩张 (BAFMD) 和冠状动脉化 (CAC) 评分.
- 统计分析使用t测试,线性回归和奇平方/费舍尔精确测试.
主要成果:
- 与对照组相比,PWH的CAD患病率 (31.9%与4.2%) 和CAC平均得分 (23.2与2.7) 显著更高.
- 在PWH中CAD与更长的ART持续时间,更高的BMI和减少的BAFMD有关.
- 高灵敏度C反应蛋白 (hsCRP) 被确定为对照组中CAD的预测因子.
结论:
- 尼日利亚北部的艾滋病毒感染者面临着更大的CAD负担,其特点是增加CAC和内皮功能障碍,无论病毒载量如何.
- 这些发现强调了将常规心血管查和预防策略整合到艾滋病毒治疗方案中的关键需求.
- 早期发现和管理心血管风险因素对于改善PWH的长期结果至关重要.
相关概念视频
Coronary Artery Disease I: Introduction
843
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
843
Coronary Artery Disease IV: Preventive Measures
563
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
563
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
358
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
358
Coronary Artery Disease II: Pathophysiology
332
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
332
Coronary Artery Disease III: Clinical Manifestations
295
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
295
Imaging Studies for Cardiovascular System III: X-Ray
447
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
447


