揭示circRNAs在pyroptotic信号中的作用:从分子交叉声到疾病调制
Tengyu Jin1,2, Guodong Xu1,2,3, Wanru Zhou1,2
1Hebei Medical University, Shijiazhuang, China.
Journal of cellular and molecular medicine
|November 24, 2025
概括
循环RNAs (circRNAs) 是新兴的激素灭绝的调节者,这是一个被编程的细胞死亡途径. 这篇综述详细介绍了circRNAs如何影响热致死机制及其在疾病中的作用,并提供了治疗见解.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 热是一种依赖气体皮质的编程细胞死亡 (PCD) 途径,其特征是细胞胀和血破裂.
- Pyroptosis释放细胞内的内容,放大炎症和免疫反应,导致各种疾病,如癌症和炎症性疾病.
- 非编码RNAs (ncRNAs),特别是循环RNAs (circRNAs),已被确定为热的关键调节者.
研究的目的:
- 系统地审查在热中circRNAs的调节机制.
- 讨论circRNAs在疾病发展中的病理生理学作用.
- 探索circRNAs在与热相关的疾病中的潜在临床应用.
主要方法:
- 关于circRNAs和pyroptosis当前研究的文献综述.
- 系统地概述了火死途径中的circRNA调节机制 (规范性,非规范性,卡斯巴-3/8介导).
- 讨论circRNAs在疾病发病和临床转化中的作用.
主要成果:
- 循环RNAs主要通过三个机制调节热亡:miRNA海绵化,蛋白质活性调节和多编码.
- 许多circRNA因其在热和相关疾病进展中的重要作用而具有特征.
- circRNAs与瘤,心血管疾病,糖尿病并发症和炎症/传染性疾病的发病有关.
结论:
- 循环RNAs通过多种分子机制在热中发挥关键的调节作用.
- 了解pyroptosis的circRNA调节对于推进有关疾病的机械洞察至关重要.
- circRNAs在诊断和治疗与热相关疾病的临床转化方面具有显著的潜力.
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