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鼻癌和微生物组:证据和影响

Zhi Yi Su¹, Wei Chung Chen¹, Pui Yan Siak¹

¹Faculty of Medicine and Health Sciences, UCSI University, Bandar Springhill, Port Dickson, Negeri Sembilan 71010, Malaysia.

Critical reviews in oncology/hematology

|November 24, 2025

概括

鼻癌 (NPC) 研究正在探索微生物组.

科学领域:

瘤学和微生物学:研究微生物群落与癌症发展,进展和治疗之间的复杂相互作用.
翻译性研究:将微生物组研究中的基础科学发现与癌症查和管理的临床应用联系起来.

背景情况:

鼻癌 (NPC) 在流行地区由于转移和晚期诊断而存在重大挑战.
人类微生物群,特别是在鼻,口腔和肠道,越来越多地被认为与NPC风险和进展有关.
瘤内微生物组可能会影响瘤微环境,影响癌症的发展和对治疗的反应.

研究的目的:

审查和整合有关微生物组与鼻癌 (NPC) 在不同身体部位之间的关联的现有证据.
确定NPC微生物组研究中的潜在研究缺口和机会.
突出在微生物组研究中对标准化方法的需求,以实现临床转化.

主要方法:

文献综述整合了与NPC相关的跨站点微生物数据.
对将微生物组成与NPC风险,进展和治疗结果相关联的研究进行分析.
检查针对NPC及其并发症的微生物组向干预措施的研究.

主要成果:

鼻,口腔和肠道中的微生物组成与NPC风险有关.
瘤内微生物组在塑造瘤微环境和影响治疗反应方面发挥着作用.
基于口腔和鼻细菌的非侵入性查工具正在开发中.
针对微生物组的策略有望缓解放射治疗引起的并发症,如口腔粘膜炎.

结论:

微生物组是NPC研究的一个有希望的领域,为新查和治疗策略提供了潜力.
需要进一步的研究,以充分阐明NPC的跨站点微生物相互作用.
研究方法的标准化对于将微生物组发现转化为NPC管理的临床实践至关重要.

关键词:

生物标志物生物标志物微生物组是一个微生物组.鼻癌是指鼻癌.口腔粘膜炎是一种口腔粘膜炎.

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