记忆T细胞捐赠者淋巴细胞输液作为治疗儿童 Haploidentical 造血干细胞移植后病毒感染的治疗方法
Yixian Li1, Yau Ki Wilson Chan1, Pui Wah Pamela Lee2
1Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong SAR, China.
Transplantation and cellular therapy
|November 24, 2025
概括
治疗性TMDLI是一种安全且可行的治疗病毒感染的治疗方法,该治疗方法是在haploidentical血造干细胞移植 (haplo-HCT) 后进行的. 这种方法有效地清除了像CMV这样的病毒再激活,改善了儿科患者的治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 病毒再激活 (CMV,EBV,ADV,HHV-6,BKV) 是 haploidentical 造血干细胞移植 (haplo-HCT) 后的主要并发症.
- 降低TCRαβ降低了移植对宿主疾病 (GVHD),但增加了延迟免疫恢复和病毒感染的风险.
- 研究CD45RA枯竭的捐赠者记忆T淋巴细胞 (TMDLI) 输液,以加速T细胞免疫力后的haplo-HCT.
研究的目的:
- 评估治疗TMDLI治疗病毒感染的安全性和可行性.
- 评估TMDLI在儿童患者在TCRαβ贫的哈普洛-HCT后100天内.
- 为了分析TMDLI在第0天进行预防性治疗.
主要方法:
- 对接受治疗TMDLI的儿科患者的回顾性审查.
- 从2020年到2023年收集的数据在一个三级儿童医院.
- 对治疗的病毒感染和患者结果的分析.
主要成果:
- 24名患者接受了46个治疗性TMDLI (12-93日后的哈普洛-HCT).
- 主要指标是CMV再激活 (69.6%);中位清除时间为14天.
- 75%的患者在30天内实现病毒清除;TMDLI耐受良好,没有新的急性GVHD.
结论:
- 治疗性TMDLI是一种安全和可行的治疗选择.
- 它有效地解决病毒感染在100天后的儿科TCRαβ-贫的Haplo-HCT.
- 在这个脆弱的人群中,DLI支持免疫恢复和病毒清除.
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