基于家庭的,动态的,多领域干预对心脏代谢多病症患者及其护理人员的认知功能的影响:"LifeWise"随机对照试验协议
Weiling Yang1, Ying Gao2, Mengjing Zhu1
1School of Public Health, Tianjin Medical University, Tianjin, China.
Journal of Alzheimer's disease : JAD
|November 24, 2025
概括
该LifeWise计划旨在预防患有心脏代谢多病症 (CMM) 的老年人及其护理人员的痴呆症. 这项研究将评估一项多领域干预措施,以改善这些双的认知功能和自我管理.
科学领域:
- 老年学与公共卫生
- 神经科学与认知衰老
- 心脏病学和新陈代谢健康
背景情况:
- 全球卫生倡议促进多领域的干预措施,以预防老年痴呆症.
- 心脏代谢多病症 (CMM) 与认知能力下降有关,但很少有干预措施针对CMM二极管.
- 该LifeWise计划通过专注于CMM患者及其护理人员来解决这一差距.
研究的目的:
- 评估LifeWise计划在延缓CMM老年人认知衰退方面的有效性.
- 评估该计划对CMM患者及其护理人员的自我管理技能的影响.
- 调查该计划对心脏代谢健康,营养,身体功能和心理健康的影响.
主要方法:
- 从中国天津的三家医院招募1220名CMM患者 (65岁以上) 和他们的护理人员.
- 中心随机化二分为干预组和对照组 (1:1比).
- 一个为期6个月的结构化多领域干预,其次是使用生态瞬间评估进行18个月的监控自我管理,在基线和6,12,18和24个月进行评估.
主要成果:
- 主要结局:CMM患者的全球认知表现.
- 二次结果:护理人员的认知表现,自我管理,护理人员的贡献,心脏代谢健康标志物 (BMI,HbA1c,FPG,BP,LDL-C),营养,身体功能,抑郁,社会隔离,痴呆发病率,再入院,死亡率和神经成像指标.
- 该研究旨在提供有关干预多方面的影响的全面数据.
结论:
- 预计LifeWise计划将验证CMM双多域干预措施的有效性.
- 这项研究将为整合痴呆症预防和双根性疾病管理策略提供证据.
- 这些发现将有助于在全球范围内管理慢性多病症.
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