支持微生物群的饮食和高脂血症:系统性炎症的调解作用
1Department of Gastroenterology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
PloS one
|November 24, 2025
概括
支持肠道微生物群的饮食模式,通过肠道微生物群的饮食指数 (DI-GM) 来衡量,与降低超脂血症风险有关. 系统性炎症部分解释了这种饮食-脂质联系.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 心血管疾病流行病学
背景情况:
- 超脂血是心血管疾病的一个关键可修改的风险因素.
- 肠道微生物群在脂质代谢中起着至关重要的作用.
- 肠道微生物群的饮食指数 (DI-GM) 评估了饮食对肠道细菌的影响,但其与高脂血症的联系需要更多的研究.
研究的目的:
- 为了研究DI-GM和高脂血症在美国大量成年人群中的关联.
- 探索系统性炎症作为这种关系中的潜在调解者的作用.
主要方法:
- 分析了来自美国21,352名成年人的数据 (2010-2020年NHANES).
- 基于24小时回忆的14种微生物群相关的饮食成分计算DI-GM.
- 使用系统性免疫炎症指数 (SII) 评估饮食-脂质关联和机制的后勤回归和调解分析.
主要成果:
- 更高的DI-GM得分与更低的超脂血症几率显著相关 (OR=0.806).
- 观察到DI-GM和高脂血症之间的剂量反应关系.
- 系统性炎症 (SII) 在DI-GM和高脂血症之间的关联中占17.8%.
结论:
- 由DI-GM评估的以微生物群为导向的饮食模式与美国成年人的高脂血症相反相关.
- 这些发现支持将微生物组为中心的饮食评估纳入脂质管理.
- 系统性炎症的部分调解表明未来研究的免疫代谢途径.
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