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Updated: Jan 10, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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细胞周期调节器PLK1通过调节转录因子BACH1来促进小鼠黑色素瘤的进展

Fengyi Mao1,2, Sai Wu1,2, Derek B Allison2,3

  • 1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America.

PLoS biology
|November 24, 2025
PubMed
概括

波罗样酶1 (PLK1) 通过重编程新陈代谢和稳定 BACH1 转录因子来驱动黑色素瘤的生长和转移. 针对PLK1与BRAFV600E一起提供了黑色素瘤的协同治疗策略.

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