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埃及非透析CKD患者的MAFLD:频率,纤维化严重程度和危险因素
Zienab M Saad1, Hesham K H Keryakos2, Hala A Hassanin1
1Department of Tropical Medicine, Faculty of Medicine, Minia University, Minya, Egypt.
PloS one
|November 24, 2025
概括
代谢功能障碍相关的脂肪肝疾病 (MAFLD) 影响了近60%的埃及非透析慢性病 (CKD) 患者. 共享的代谢因素推动了这种高患病率,表明需要综合护理策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 在非透析慢性病 (CKD) 患者中,代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的患病率基本上是未知的,特别是在代谢障碍率高的埃及人群中.
- 慢性脏病和MAFLD具有共同的代谢风险因素,这表明这些疾病之间存在潜在的联系.
研究的目的:
- 确定埃及非透析CKD患者中MAFLD的发生频率.
- 评估这些患者肝纤维化的严重程度.
- 在这个队列中确定与MAFLD相关的代谢风险因素.
主要方法:
- 一项横截面研究包括108名非透析的CKD患者.
- MAFLD的诊断是基于肝硬化和代谢风险因素.
- 肝纤维化被评估使用非侵入性得分 (NAFLD得分,FIB-4,APRI) 和剪切波弹性图.
主要成果:
- 在非透析的埃及慢性病患者中,MAFLD的患病率为59.25%.
- MAFLD与年龄较大,BMI较高,糖尿病,高血压和胰岛素抵抗有显著的关联.
- 在MAFLD患者中,估计的淋巴球过率 (eGFR) 较低,肝硬度增加,晚期CKD阶段晚期纤维化更为常见.
结论:
- 在非透析CKD患者中,MAFLD非常普遍,与共享的代谢异常和CKD严重程度有关.
- 在MAFLD和CKD之间存在双向关系.
- 综合查和管理策略对于减轻这一群体的进展风险至关重要.
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