睡眠呼吸暂停对55岁以下人视网膜静脉封闭的影响:一项回顾性队列研究
Shon Shmushkevich1,2, Shannan Berzack2, Sandi Bajrami3
1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Retina (Philadelphia, Pa.)
|November 24, 2025
概括
睡眠呼吸暂停 (SA) 在55岁以下的成年人中增加了视网膜静脉封闭 (RVO) 的风险. 早期治疗SA对于预防视力威胁的并发症至关重要,例如分支视网膜静脉封闭 (BRVO).
科学领域:
- 眼科医生 眼科 眼科
- 睡眠医学 睡眠医学
- 血管医学 血管医学
背景情况:
- 睡眠呼吸暂停 (SA) 是一个已知的系统性血管风险因素.
- 在年轻成年人中,SA和视网膜静脉封闭 (RVO) 之间的关联仍未得到充分研究.
研究的目的:
- 调查SA与RVO发生率之间的关系,包括中央 (CRVO) 和分支视网膜静脉封闭 (BRVO).
- 为了评估这一关联,特别是在55岁或更年轻的个体中.
主要方法:
- 一项回顾性队列研究利用了TrinetX美国协作网络 (2005-2025年).
- 倾向性得分匹配创造了1:1的SA患者队列 (N=2,087,539) 和基于年龄,性别,种族,BMI和并发症的对照组 (N=2,087,539).
- 事件RVO,CRVO和BRVO使用风险比率,危险比率和Kaplan-Meier生存分析进行评估.
主要成果:
- 与对照组相比,SA患者患RVO的风险明显更高 (RR=1.152,HR=1.219).
- 在SA组中,分支视网膜静脉封闭 (BRVO) 的风险特别高 (RR=1.287,HR=1.367).
- 对于RVO和BRVO结局均观察到统计学意义 (p < 0.05).
结论:
- 睡眠呼吸暂停与年轻成年人视网膜静脉封闭的风险增加有关.
- 分支视网膜静脉封闭 (BRVO) 是这种风险增加的主要驱动因素.
- 建议早期检测和管理SA,以预防视网膜血管并发症.
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