一个T1阶段乳腺癌的生存分析和名谱发育:基于SEER数据库
Lizhi Teng1, Yuhan Dong1, Juntong Du1
1Department of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, Harbin, China; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China; NHC Key Laboratory of Cell Transplantation, Heilongjiang, China.
Clinics (Sao Paulo, Brazil)
|November 24, 2025
概括
这项研究开发了一种名谱,用于预测早期乳腺癌 (T1) 的结果. 该工具准确地预测了长达10年的整体存活率 (OS) 和乳腺癌特定存活率 (BCSS).
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 癌症研究 癌症研究
背景情况:
- 乳腺癌 (BC) 是一种常见的恶性瘤,T1期瘤通常具有良好的预后.
- 然而,对于早期 (T1) 乳腺癌,治疗和预后的不确定性仍然存在.
研究的目的:
- 开发和验证用于预测T1期乳腺癌患者的整体存活率 (OS) 和乳腺癌特异性存活率 (BCSS) 的名图.
- 确定影响乳腺癌早期预后的关键临床病理和治疗因素.
主要方法:
- 利用了监测,流行病学和最终结果 (SEER) 计划 (2010-2015) 中164,906名女性患者的数据.
- 进行多因素分析以确定OS和BCSS的预后变量.
- 构建了一个包含显著独立预后因素的名录图.
主要成果:
- 多变量分析确定了年龄,种族,学年级,T阶段,N阶段,化疗,辐射,手术,雌激素受体 (ER),孕激素受体 (PR) 和人类表皮生长因子受体-2 (HER2) 状态作为OS和BCSS的重要因素.
- 诺米图表表现出良好的预测准确性,AUC值为3年,5年和10年的OS和BCSS>0.7.
- 验证曲线 (ROC,校准,DCA) 证实了名图的可预测性和临床益处.
结论:
- 在T1a,T1b和T1c乳腺癌亚组中,预后有很大差异.
- 开发的诺米图为预测乳腺癌早期的3,5年和10年的OS和BCSS提供了可靠的工具.
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