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来自内性真菌Xylaria sp.的抗真菌厄戈斯坦类型类固醇. 这就是VDL4的原因

Jiao Yao¹, Lin-Hong Lu¹, Sheng-Yun Wei¹

¹Key Laboratory of State Forestry Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650224, China.

|November 24, 2025

概括

在真菌中发现了两种新的ergotane类固醇,xylarstane A和B,Xylaria sp. 这些化合物与已知的类固醇一起,对植物病原体表现出显著的抗真菌活性.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
药用植物研究药用植物研究

背景情况:

居住在药用植物中的内菌是生物活性天然产品的丰富来源.
药用植物Vaccinium dunalianum是内性真菌的庇护所,有可能发现新的化合物.

研究的目的:

从内性真菌Xylaria sp.中分离和鉴定埃尔戈斯坦类型的类固醇. 这是VDL4.
评估隔离化合物的抗真菌潜力,以对抗关键的植物病原体.

主要方法:

使用综合光谱分析 (NMR,ECD) 来分离和阐明化合物的结构.
通过DP4+理论计算对新型化合物的结构确认.
在体外抗真菌活性测定对四种植物病原体.

主要成果:

确定了两种新型的ergotane类固醇,xylarstane A (1) 和xylarstane B (2),以及一个已知的化合物 (3).
化合物1和3对相应的Alternaria solani和Botrytis cinerea表现出显著的抗真菌活性.
活性化合物的最小抑制度 (MIC) 为12.5μg/ml,与阳性对照相比.

结论:

克西拉利亚 sp. VDL4是一种具有潜在农业应用的生物活性厄戈斯坦类固醇的来源.
已识别的化合物表现出有前途的抗真菌特性,对抗重要的植物疾病.
对这些类固醇的进一步研究可能会导致开发新的抗真菌剂.

关键词:

它具有抗真菌活性,具有抗真菌活性.这是内性真菌.埃尔戈斯坦类型的类固醇这种疫苗叫做Vaccinium dunalianum.克西拉利亚 sp.

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