诊断和管理患有巨细胞激活综合征的患者:状态 2026
Cem Akin1, Theo Gülen2, Mariana C Castells3
1Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Mich.
The journal of allergy and clinical immunology. In practice
|November 24, 2025
概括
人们越来越多地诊断出乳腺细胞激活障碍 (MCAD),包括乳腺细胞激活综合征 (MCAS). 本综述澄清了MCAD的诊断标准和治疗方法,强调了准确的诊断来管理这些复杂的疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏 过敏是一种过敏.
- 血液学 血液学 血液学
背景情况:
- 巨细胞激活障碍 (MCAD) 包含涉及不适当的巨细胞激活的疾病,全球患者转诊数量不断增加.
- 巨细胞激活综合征 (MCAS) 是MCAD中的一个独特的实体,其特点是特定的症状,介质释放和治疗反应.
- 意识的提高,过敏性疾病的流行率和在线信息有助于增加MCAD诊断,尽管诊断标准仍然是一个挑战.
研究的目的:
- 为MCAS和其他MCAD提供当前诊断标准,测试和标准的概述.
- 为MCAD提供治疗选择的最新审查.
- 讨论差异诊断对于准确的MCAS诊断至关重要.
主要方法:
- 对MCAD可用的诊断标准和测试进行审查.
- 对MCAS的建议和应用诊断标准的分析.
- 对治疗策略和差异诊断的文献综述.
主要成果:
- 对于MCAS和其他MCAD的诊断标准不是普遍应用或接受的,这使诊断复杂化.
- 准确的诊断需要满足严格的标准,以确认巨细胞的参与.
- 对诊断方法和治疗选择有全面的了解是必不可少的.
结论:
- 需要对MCAS和其他MCAD进行标准化和一致应用的诊断标准.
- 有效管理MCAD依赖于准确的诊断,适当的治疗,并考虑差异诊断.
- 本综述旨在指导医疗保健提供者在诊断和管理疑似巨细胞激活障碍患者时.
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