在儿童中控制乳腺细胞和乳腺细胞激活的管理
Melody C Carter1, Magdalena Lange2, Ivan Alvarez-Twose3
1Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
儿科巨细胞瘤,通常限于皮肤,通常在青春期自发消失. 基因突变在KIT基因是常见的,诊断依赖于非侵入性方法.
科学领域:
- 儿科血液学 儿科血液学
- 皮肤病学 皮肤病学
- 遗传学 是一个遗传学.
背景情况:
- 巨细胞症涉及巨细胞透到组织中,经常影响儿童.
- 儿科巨细胞瘤与成人形式不同,通常是短暂的,并在青春期消失.
研究的目的:
- 要总结儿科巨细胞瘤的关键特征.
- 为了区分儿科和成人乳腺细胞瘤.
- 概述儿科巨细胞瘤的诊断和治疗策略.
主要方法:
- 对临床表现和自然史的审查.
- 对基因突变的分析,特别是在KIT基因中.
- 诊断方法和治疗选择的总结.
主要成果:
- 大多数儿科乳腺细胞瘤是皮肤的,呈现为黄斑状病变或乳腺细胞瘤.
- 过渡性疾病的过程与自发的解决是常见的儿童.
- KIT基因突变很普遍,KIT D816V在全身性疾病中很常见.
结论:
- 儿科巨细胞瘤是明显的,往往是短暂的,主要是皮肤的.
- 诊断采用非侵入性方法,包括皮肤检查和遗传分析.
- 管理涉及触发回避,抗组胺药物和针对系统性形式的向治疗.
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