关于免疫检查点抑制剂的皮肤毒性最新情况
Davide Fattore1, Giuseppe Lauletta1, Cecile Pages2
1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Presse medicale (Paris, France : 1983)
|November 24, 2025
概括
免疫检查点抑制剂 (ICI) 治疗癌症,但可能导致皮肤免疫相关不良事件 (irAEs). 本综述涵盖了它们的原因,症状和管理,并指出一些皮肤毒性可能预测治疗成功.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 免疫检查点抑制剂 (ICI) 通过向CTLA-4,PD-1和PD-L1通路来彻底改变癌症治疗.
- 通过ICI系统性免疫激活可以导致与免疫相关的不良事件 (irAEs).
- 皮肤上注射的IRAE很常见,从轻微的皮疹到严重的疾病,如史蒂文斯-约翰逊综合征.
研究的目的:
- 提供与免疫检查点抑制剂 (ICI) 相关的皮肤免疫相关不良事件 (irAEs) 的全面审查.
- 讨论这些皮肤毒性的流行病学,病理生理学,临床表现,诊断和管理.
- 探索皮肤毒性和抗瘤反应之间的潜在相关性.
主要方法:
- 对ICI诱导的皮肤IRAE研究的文献综述.
- 对流行病学数据,病理生理机制和临床表现的分析.
- 综合当前的诊断和管理策略.
主要成果:
- 皮肤上注射的IRAE具有广泛的自身免疫反应,影响患者的生活质量.
- 像史蒂文斯-约翰逊综合征和有毒表皮解等严重的irrAEs需要及时管理.
- 某些皮肤毒性可以作为有利于ICI的抗瘤反应的预测生物标志物.
结论:
- 了解和管理皮肤IRAE对于优化ICI治疗至关重要.
- 早期识别和适当治疗皮肤毒性可以减轻患者的发病率.
- 需要进一步研究皮肤iRAE与治疗疗效之间的联系.
相关概念视频
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
01:23Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
01:27Cytotoxic T Cells-mediated Immune Response
6.4K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.4K
01:25Immunodeficiency Diseases
1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.9K
01:40Cell-mediated Immune Responses
83.4K
Overview
83.4K
01:19Clinical Applications of Epidermal Stem Cells
3.2K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.2K