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由免疫检查点抑制剂诱导的Sicca

Rakiba Belkhir¹, Marjolaine Gosset², Antoine Rousseau³

¹Rheumatology Department, FHU CARE, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris, France.

Presse medicale (Paris, France : 1983)

|November 24, 2025

概括

免疫检查点抑制剂 (ICI) 可以引起西卡综合征,影响5-24%的患者. 早期发现和管理,与Sjögren病不同,对于改善患者的生活质量至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

免疫检查点抑制剂 (ICI) 已经改变了癌症治疗.
免疫相关的不良事件 (irAEs) 在ICI中很常见,包括sicca综合征 (眼睛/口腔干燥).
ICI诱导的西卡综合征是未被认可的,并影响患者的生活质量.

研究的目的:

审查ICI诱导的西卡综合征的患病率,临床特征和管理.
区分ICI诱导的疾病与Sjögren病 (SjD).
强调早期检测和治疗策略.

主要方法:

文献综述侧重于ICI诱导的西卡综合征.
流行率,临床表现和病理生理学的分析.
评估当前和拟议的管理策略.

主要成果:

据估计,ICI诱导的sicca会影响5-24%的患者.
病理生理学涉及T淋巴细胞透唾液腺,不同于SjD.
治疗包括症状缓解和皮质类固醇.

结论:

由ICI引起的sicca是一种需要注意的显著的IRAE.
需要进一步研究频率,查,早期治疗和长期结果.
多学科合作对于制定指南和改善患者护理至关重要.

关键词:

干燥干燥干燥免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.西卡卡西卡是一座城市.斯约格伦病是斯约格伦病的一种疾病.

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