与年龄相关的视神经光学连贯性断层扫描和光学连贯性断层扫描 血管扫描 没有玻璃眼症的受试者的变化:一项为期5年的前性研究
Ruiqi Pang1, Ajay Kolli2, Rui Li1
1From the Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Laboratory (R.P., R.L., M.L., K.C., F.X., L.S., S.W., Z.W., Zehua W., S.L.), Capital Medical University, Beijing, China.
American journal of ophthalmology
|November 24, 2025
概括
正常的衰老会导致视神经和视网膜层厚度下降,以及血管密度下降. 这些与年龄相关的变化对于诊断青光眼的诊断很重要.
科学领域:
- 眼科医生 眼科 眼科
- 老年学是一门学科.
- 医疗成像医学成像
背景情况:
- 视神经和斑点的与年龄相关的变化是常见的.
- 光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA) 是关键的成像技术.
- 区分正常的老化和青光眼对于准确的诊断至关重要.
研究的目的:
- 通过使用OCT和OCTA来描述视神经的非白内障性与年龄相关的变化.
- 为关键的眼部结构建立规范性衰老数据.
主要方法:
- 一项前性队列研究,对579名50岁以上的参与者进行了前性队列研究.
- 基线和5年随访OCT和OCTA成像.
- 测量包括周状视网膜神经纤维层 (pRNFL) 和黄斑质细胞综合体 (mGCC) 厚度,以及黄斑血管密度.
主要成果:
- 在pRNFL厚度 (1.7微米),mGCC厚度 (0.8微米),表面黄斑血管密度 (2.4%) 和辐射周毛细血管 (RPC) 密度 (0.3%) 中观察到显著的5年下降.
- 与高脂血症和眼内压力相关的mGCC下降.
- 与脉,静脉血压,年龄和轴长度相关的RPC下降.
结论:
- 正常的衰老导致pRNFL,mGCC,RPC密度和表面黄斑血管密度的可测量下降.
- 这些与年龄相关的规范性变化必须在青光眼的诊断和监测中考虑.
- OCT和OCTA为与年龄相关的眼睛结构和血管变化提供了宝贵的见解.
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